ROME (AP) — The first day of June saw coronavirus restrictions ease from Asia to Europe to the United States on Monday, even as U.S. protests against police brutality sparked fears of new outbreaks.

The Florida Keys welcomed visitors for the first time in two months, the Colosseum opened its ancient doors in Rome, ferries restarted in Bangladesh, golfers played in Greece and students returned to classes in Britain.

But even as the tourist-dependent Keys took down barriers to allow visitors, Miami-Dade County kept its beaches closed because of protests in South Florida and across the country over the May 25 death of George Floyd, a black man pinned at the neck by a white police officer in Minneapolis.

Meanwhile, a California biotech company said its experimental drug remdesivir improved symptoms when given for five days to moderately ill, hospitalized patients with COVID-19. Gilead Sciences gave few details but said full results would soon be published in a medical journal. Remdesivir is the only treatment that’s been shown in a rigorous experiment to help fight the coronavirus.

Roadblocks were taken down shortly after midnight near Key Largo, the northernmost island in the Florida chain, where almost half of all workers are employed by hotels, bars and other hospitality industries, and many of the rest are involved in commercial and sport fishing.

Richard Stanczyk, owner of Bud N’ Mary’s marina in Islamorada, said the 40 captains who operate fishing boats out of the 76-year-old business have had virtually no customers for weeks and welcomed the reopening of the area to visitors.

“There has been a real uptick in phone calls. There have been more charter bookings,” Stanczyk said. “We are encouraged. It’s going to come back.”

Yet the carefree, party atmosphere that surrounds the Keys and was popularized by singer Jimmy Buffet in songs like “Margaritaville” may not return for some time. The Monroe County Tourist Development Council made clear on its website that visitors must adhere to health guidelines.

“Bring facial coverings, gloves, hand sanitizer, reef-safe sunscreen and personal essential medicines. If you’re feeling unwell, please stay home,” it said.

The Keys have been relatively unscathed by the coronavirus. As of Sunday, the island chain had 100 confirmed cases, three deaths and 12 hospitalizations. The total population is just under 80,000.

Countries around the Mediterranean Sea also tentatively kicked off a summer season where tourists could bask in their famously sunny beaches while still being protected by social distancing measures from the virus marching relentlessly around the world.

“We are reopening a symbol. A symbol of Rome, a symbol for Italy,” said Alfonsina Russo, director of the Colosseum’s archaeological park. “(We are) restarting in a positive way, with a different pace, with a more sustainable tourism.”

Greece lifted lockdown measures for hotels, campsites, open-air cinemas, golf courses and public swimming pools, while b eaches and museums reopened in Turkey and bars, restaurants, cinemas and museums came back to life in the Netherlands.

“Today, we opened two rooms and tomorrow three. It’s like building an anthill,” Athens hotel owner Panos Betis said as employees wearing face masks tidied a rooftop restaurant and cleaned a window facing the ancient Acropolis. “We can’t compare the season to last year. We were at 95% capacity. Our aim now is to hang in there until 2021."

A long line of masked visitors snaked outside the Vatican Museums, which include the Sistine Chapel, as they reopened for the first time in three months. Italy is eager to reboot its tourism industry, which accounts for 13% of its economy.

The Vatican Museums’ famous keyholder — the “clavigero” who holds the keys to all the galleries on a big ring on his wrist — opened the gate in a sign both symbolic and literal that the Museums were back in business.

Still, strict crowd control measures were in place: Visitors needed reservations to visit, their temperatures were taken before entering and masks were mandatory.

“Having the opportunity to see the museums by making a booking and not having to wait in line for three hours is an opportunity,” said visitor Stefano Dicozzi.

The Dutch relaxation of coronavirus rules took place on a major holiday with the sun blazing, raising fears of overcrowding in popular beach resorts. The new rules let bars and restaurants serve up to 30 people inside if they keep social distancing, but there's no standing at bars and reservations are necessary.

Britain, which with over 38,500 dead has the world's second-worst death toll behind the United States, eased restrictions despite warnings from health officials that the risk of spreading COVID-19 was still too great. Some elementary classes reopened in England and people could now have limited contact with family and friends, but only outdoors and with social distancing.

Around 6.19 million infections have been reported worldwide, with over 372,000 people dying, according to a tally by Johns Hopkins University. The true death toll is believed to be significantly higher, since many died without ever being tested.

In the U.S., the often-violent protests over Floyd's death have raised fears of new outbreaks in a country that has more confirmed infections and deaths than any other. The U.S. has seen nearly 1.8 million infections and over 104,000 deaths in the pandemic, which has disproportionately affected racial minorities.

Protests over Floyd’s death have shaken the U.S. from New York to Los Angeles. Demonstrators are packed cheek by jowl, many without masks, many shouting or singing. The virus is spread by microscopic droplets in the air when people cough, sneeze, talk or sing.

New York Gov. Andrew Cuomo expressed concern Monday the protests in New York City could imperil the long, hard fight to contain the pandemic in a worldwide hot spot.

“You turn on the TV and you see these mass gatherings that could potentially be infecting hundreds and hundreds of people after everything that we have done,” Cuomo said. “We have to take a minute and ask ourselves: ’What are we doing here?”

Some efforts to contain the spread of coronavirus are being upended by the protests. In contact tracing, newly infected people list everyone they’ve interacted with over several days in order to alert them that they may have been exposed — a daunting task if someone has been to a mass gathering.

Central and South America are currently witnessing the most intense transmission of the coronavirus worldwide, according to the World Health Organization. In the last 24 hours, the WHO's Dr. Michael Ryan said five of the 10 countries reporting the highest number of cases are in the Americas: the U.S., Brazil, Peru, Chile and Mexico.

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Anderson reported from St. Petersburg, Florida. Reporters from around the world contributed to this report.

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